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KMID : 0605720070130010097
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Journal of the Korean Society of Biological Therapies in Psychiatry
2007 Volume.13 No. 1 p.97 ~ p.103
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Therapeutic Response to Antipsychotics and Long-Term Body Weight Gain in Schizophrenic Patients
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Kim Hee-Cheol
Jung Sung-Won
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Abstract
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Objectives : Clinically significant weight gain is associated with some commonly prescribed antipsychotics and some studies reported a positive association between symptom improvement and gain in body weight during antipsychotics treatment. The purpose of this study was to investigate the relationship between the therapeutic response to antipsychotics and long-term body weight gain after administration of those drugs.
Methods : This is a retrospective chart review of 200 consecutively hospitalized patients with the diagnosis of schizophrenia(DSM-IV) treated with various antipsychotics(94% atypical antipsychotics) at Bugok National Hospital, Korea. The patients were divided into two groups, responders and non-responders, by responsiveness to antipsychotics according to a four-point scale used in previous studies；responders included moderate to marked responded patients and non-responders included none to minimal responded patients. The patients were also divided into another two groups, weight gainers(weight gai ≥5%) and non-gainers(weight gain＜5%) by percentile change of body weight at discharge compared to body weight at admission. We compared sociode-mographic and weight-related variables between responders and non-responders.
Results : Among the total patients of 200,141(70.5%) were categorized as responders and 73(36.5%) were categorized as weight gainers. There were no significant differences between responders and non-responders in age at index admission, sex, education, marital status, family history, age at first onset, duration of index admission, number of previous hospitalization, type of schizophrenia, body weight and body mass index(BMI) at admission. The responders(3.2±9.9㎏) experienced significantly more weight gain at discharge than the non-responders(-1.3 ±8.9㎏)(t=2.99, p=0.00). Weight gainers were significant more frequent in responders than non-responders.
Conclusion : These results show that the antipsychotics-induced long-term body weight gain is associated with therapeutic response to antipsychotics in schizophrenic patients. A prospective, randomized, placebo controlled study is required to further establish the association between antipsychotic response and weight gain in the future.
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KEYWORD
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Antipsychotic agents, Treatment response, Weight gain, Schizophrenia
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